Steven P. Roose is Professor of Clinical Psychiatry at the College of Physicians & Surgeons, Columbia University and Director of the Neuropsychiatry Research Clinic at the New York State Psychiatric Institute.
Dr. Roose did his undergraduate work at Harvard University and attended medical school at the Mount Sinai School of Medicine. After medical internship, Dr. Roose completed his psychiatric residency at Columbia Presbyterian — New York State Psychiatric Institute and subsequently an NIMH-sponsored research fellowship in affective disorders.
Roose is also a graduate of the Center for Psychoanalytic Training and Research, Columbia University and is Director of the Research Committee at the Columbia Center. He serves on the Research Committees of the International Psychoanalytic Association, and the American Psychoanalytic Association.
Research Focus
Dr. Roose’s research has focused on the phenomenology, psychobiology and treatment of affective disorders with a specific concentration on the relationship between cardiovascular disease and depression and more recently on the treatment of late-life depression.
Over the past 10 years, Dr. Roose’s research group in the Psychoanalytic Center has conducted studies on the feasibility of applying psychotherapy research methods to psychoanalysis, systematic studies of psychoanalytic education including supervision, patient/therapist match, antidepressant use during psychoanalysis and post-termination contact.
He has authored or coauthored over 200 articles as well as co-edited or authored six books. He currently serves on the editorial board of a number of journals including the Journal of Clinical Psychiatry, Heart Disease and the Journal of the American Psychoanalytic Association
Select Publications
1. Roose SP, Laghrissi-Thode F, Kennedy JS, Nelson JC, Bigger JT, Pollock BG, Gaffney A, Narayan M,Finkel MS, McCafferty J,, Gergel I. A comparison of paroxetine to nortriptyline in depressed patients with ischemic heart disease. JAMA 279:287-291, 1998. PMID: 9450712
2. Roose SP, Glassman AH, Seidman SN. Relationship between depression and other medical illnesses. JAMA 286(14):1687-1690, 2001. PMID: 11594878
3. Roose SP, Sackeim HA. Clinical Trials in late-life depression revisited. Am J Geriatr Psychiatry 10(5):503-506. 2002. PMID: 12213683
4. Roose SP. Treatment of Depression in Patients with Heart Disease. Biological Psychiatry. 54(3):262-268, 2003. PMID: 12893102
5. Roose SP, Yeragani V. Antidepressants and mortality in depressed patients with concomitant illness. European Neuropsychopharmacology 2003.
6. Roose SP, Miyazaki M, Devanand D, Seidman S, Fitzsimmons L, Turret N, Sackheim H. An open trial of venlafaxine for the treatment of late life atypical depression. International Journal of Geriatric Psychiatry, 9:989-994. 2004. PMID: 15449363
7. Roose SP, Sackeim HA, Krishnan KR, Pollock BG, Alexopoulos G, Lavretsky H, Katz IR, Hakarainen H. Old-Old Depression Study Group. Antidepressant Pharmacotherapy in the treatment of depression in the very old: A randomized, placebo controlled trial. American Journal of Psychiatry. 161(11):2050-2059, 2004.PMID: 15514405
8. Roose SP, Sackeim HA, eds. Late Life Depression. Oxford University Press: New York 2004.
9. Sackheim HA, Roose SP, Lavori PW. Determining the duration of antidepressant treatment: Application of signal detection methodology and the need for duration adaptive designs (DAD). Biological Psychiatry, 59(6):483-92, 2006. PMID: 16517241
10. Sneed JR, Rindskopf D, Steffens DC, Krishnan RR, Roose SP. The vascular depression subtype, evidence of internal validity. Biological Psychiatry. 64(6):491-7. 2008. PMID: 18490003, PMCID: PMC2597784
11.Rutherford BR, Cooper TM, Persaud A, Brown PJ, Sneed JR, Roose SP. Less is more in antidepressant clinical trials; A meta-analysis of the effect of visit frequency on treatment response and drop-out. J Clin Psychiatry. 2013 Jul;74(7):703-15.
12. Culang M, Sneed JR, Keilp J, Butters M, Rutherford BR, Roose SP. The impact of Antidepressant Treatment on Cognitive Functioning of Depressed Older Adults. American Journal of Geriatric Psychiatry.17(10):881-888, 2009. PMI|D: 19916207.
13. Rutherford B, Sneed J, Eisenstadt R, Roose SP. Antidepressant study design affects patient expectations: results from a pilot randomized controlled trial. Psychological Med. 40(5):781-788. 2010. PMID: 1973248.
14. Brown, P.J. & Roose, S.P. (2011). Age and anxiety and depressive symptoms: the effect on domains of quality of life. Inter J of Geri Psychiatry, 26(12):1260-1266. 2011. PMID: 21351152.
15.Rutherford BR, Roose SP. A model of placebo response in antidepressant clinical trials. Am J Psychiatry. 20013;170:723-733